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Apple peel could be used to fight Rotavirus

Ursolic acid that is present in the peel, bark of stems and leaves of the apple may inspire a specific
Science
La cáscara de manzana podría servir para combatir el Rotavirus
| 30 December, 2019 |

According to a study conducted by scientists fromMendoza,the acid ursolic that is present in the apple peel, bark ofstems, leaves and dried fruits could inspire a specific treatment for Rotavirus. According to research,published by the Agency CyTA -Foundation Leloir,ursolic acid is a vegetable compound with a wide range of of pharmaceutical properties.

Now, Argentine researchers have shown that it has the ability to inhibit Rotavirus, which causes severe diarrhea in children up to 5 years old and neonates. “There is no specific treatment available for Rotavirus infections, so we want our finding to be a contribution to achieving that goal,” the director of the study ,Dr. Laura Delgui, a researcher at the Institute of Histology and Embryology of Mendoza (IHEM), a dependent the Conicet and the Faculty of Medical Sciences of the National University of Cuyo (UNCuyo).

Advances

As an article in the International Journal of Antimicrobial Agentsreveals, Delgui and colleagues managed to interfere with the Rotavirus lifecycle by treating cells infected with that plant compound. For their laboratory experiments, the study authors used a virus strain adapted to growth in vitro, called SA11 .

At present, the group of virologous scientists in Mendoza is working on studying the molecular mechanism that mediates the antiviral effect of ursolic acid. “ It is necessary to know to cure,” Delgui said. The next experiments will be aimed at testing the activity of the plant compound in laboratory animals infected with Rotavirus, such as mice, as well as against viruses isolated from human patients .

“ Developing a drug requires a very long path in which our group will require the collaboration of field experts such as chemicals, pharmacists and researchers from the pharmaceutical industry,” said Delgui.

Source: Diario Los Andes

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