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Apple peel could be used to combat rotavirus

Ursolic acid that is present in the peel, bark of stems and leaves of the apple could inspire a specific treatment against Rotavirus.

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According to a study by scientists from Mendoza, ursolic acid that is present in apple peel, stems bark, leaves and dried fruits could inspire a specific treatment for Rotavirus . According to research, published by the Agency CyTa -Leloir Foundation, ursolic acid is a plant compound with a wide range of pharmaceutical properties.

Now, Argentine researchers have shown that it has the ability to inhibit Rotavirus, which causes severe diarrhea in children up to 5 years of age and neonates.  “ There is no specific treatment available for Rotavirus infections, so we want our finding to be a contribution to achieving that goal,” the director of the study, Dr. Laura Delgui, researcher at the Institute of History, told the Cyta-Leloir Agency.iacute; a and Embryology of Mendoza (IHEM), dependent on the Conicet and the Faculty of Medical Sciences of the National University of Cuyo (UNCuyo). 

 Advances 

As an article in the   International Journal of Antimicrobial Agents reveals,  Delgui and her colleagues managed to interfere with the rotavirus life cycle by  treating infected cells with that vegetable compound.  For their laboratory experiments, the authors of the study used a virus strain adapted to growth in vitro, called SA11.

At present, the group of virologist  scientists  from Mendoza is working on studying the molecular mechanism that medians the antiviral effect of the disease.ursolic acid.  “ It is necessary to know to cure,” said Delgui.  The next experiments will be aimed at testing the activity of the plant compound in laboratory animals infected with Rotavirus, such as mice, as well as against viruses isolated from human patients.

“Developing a drug requires a  very long road  in which our group will require the collaboration of experts from the field such as chemists, pharmacists and researchers from the pharmaceutical industry,” said Delgui.

Source:  Diario Los Andes 

Publication Date: 30/12/2019

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